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Oncolytic viral therapy for pancreatic cancer: current research and future directions

Authors Ady JW, Heffner J, Klein E, Fong Y

Received 1 September 2013

Accepted for publication 2 December 2013

Published 17 February 2014 Volume 2014:3 Pages 35—46

DOI https://doi.org/10.2147/OV.S53858

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Justin W Ady, Jacqueline Heffner, Elizabeth Klein, Yuman Fong

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

Abstract: The development of targeted agents and chemotherapies for pancreatic cancer has only modestly affected clinical outcome and not changed 5-year survival. Fortunately the genetic and molecular mechanisms underlying pancreatic cancer are being rapidly uncovered and are providing opportunities for novel targeted therapies. Oncolytic viral therapy is one of the most promising targeted agents for pancreatic cancer. This review will look at the current state of the development of these self-replicating nanoparticles in the treatment of pancreatic cancer.

Keywords: pancreatic cancer, oncolytic virus, review

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