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Omics-Driven Biomarkers of Psoriasis: Recent Insights, Current Challenges, and Future Prospects

Authors Aydin B, Arga KY, Karadag AS

Received 20 June 2020

Accepted for publication 7 August 2020

Published 25 August 2020 Volume 2020:13 Pages 611—625

DOI https://doi.org/10.2147/CCID.S227896

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Busra Aydin,1 Kazim Yalcin Arga,1 Ayse Serap Karadag2

1Department of Bioengineering, Faculty of Engineering, Marmara University, Istanbul, Turkey; 2Department of Dermatology, Istanbul Medeniyet University, School of Medicine, Goztepe Research and Training Hospital, Istanbul, Turkey

Correspondence: Ayse Serap Karadag
Department of Dermatology, Istanbul Medeniyet University, School of Medicine, Goztepe Research and Training Hospital, Istanbul, Turkey
Tel +90 5336552260
Fax +90 216 566 66 14
Email karadagaserap@gmail.com

Abstract: Advances in omics technologies have made it possible to unravel biomarkers from different biological levels. Intensive studies have been carried out to uncover the dysregulations in psoriasis and to identify molecular signatures associated with the pathogenesis of psoriasis. In this review, we presented an overview of the current status of the omics-driven biomarker research and emphasized the transcriptomic, epigenomic, proteomic, metabolomic, and glycomic signatures proposed as psoriasis biomarkers. Furthermore, insights on the limitations and future directions of the current biomarker discovery strategies were discussed, which will continue to comprehend broader visions of psoriasis research, diagnosis, and therapy especially in the context of personalized medicine.

Keywords: psoriasis, biomarker, omics, inflammatory skin diseases, personalized medicine, psoriasis biomarkers, omics biomarkers

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