Back to Journals » Clinical Interventions in Aging » Volume 5

Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease

Authors Jicha G, Markesbery WR

Published 25 March 2010 Volume 2010:5 Pages 45—61

DOI https://doi.org/10.2147/CIA.S5231

Review by Single-blind

Peer reviewer comments 6

Gregory A Jicha, William R Markesbery

University of Kentucky Alzheimer’s Disease Center and the Sanders-Brown Center on Aging University of Kentucky College of Medicine, Lexington, KY, US

Abstract: Omega-3 fatty acids are essential for brain growth and development. They play an important role throughout life, as critical modulators of neuronal function and regulation of oxidative stress mechanisms, in brain health and disease. Docosahexanoic acid (DHA), the major omega-3 fatty acid found in neurons, has taken on a central role as a target for therapeutic intervention in Alzheimer’s disease (AD). A plethora of in vitro, animal model, and human data, gathered over the past decade, highlight the important role DHA may play in the development of a variety of neurological and psychiatric disorders, including AD. Cross sectional and prospective cohort data have demonstrated that reduced dietary intake or low brain levels of DHA are associated with accelerated cognitive decline or the development of incipient dementia, including AD. Several clinical trials investigating the effects of omega-3 fatty acid supplementation in AD have been completed and all failed to demonstrate its efficacy in the treatment of AD. However, these trials produced intriguing data suggesting that the beneficial effects of omega-3 fatty acid supplementation may depend on the stage of disease, other dietary mediators, and apolipoprotein E status.
Keywords: Alzheimer’s disease, omega-3 fatty acids, oxidative stress, clinical studies, treatment

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]