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Olaparib in the management of ovarian cancer

Authors Bixel K, Hays JL

Received 29 April 2015

Accepted for publication 22 June 2015

Published 7 August 2015 Volume 2015:8 Pages 127—135

DOI https://doi.org/10.2147/PGPM.S62809

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Martin Bluth

Kristin Bixel,1 John L Hays2

1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, 2Department of Hematology Oncology, Ohio State University, Columbus, OH, USA

Abstract: Alterations in the homologous repair pathway are thought to occur in 30%–50% of epithelial ovarian cancers. Cells deficient in homologous recombination rely on alternative pathways for DNA repair in order to survive, thereby providing a potential target for therapy. Olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, capitalizes on this concept and is the first drug in its class approved for patients with ovarian cancer. This review article will provide an overview of the BRCA genes and homologous recombination, the role of PARP in DNA repair and the biological rationale for the use of PARP inhibitors as cancer therapy, and ultimately will focus on the use of olaparib in the management of ovarian cancer.

Keywords: 
olaparib, ovarian cancer, PARP inhibitor

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