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Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine

Authors Fornaro M 

Published 29 October 2010 Volume 2010:6(1) Pages 719—722


Review by Single anonymous peer review

Peer reviewer comments 5

Michele Fornaro

Department of Neuroscience, Section of Psychiatry, University of Genoa, Genoa, Italy

Abstract: Isotretinoin, a drug used for moderate to severe acne, has been repeatedly associated with various psychiatric complications, although a definitive causal relationship has not been established to date. This case report describes a 25-year-old male who developed obsessive-compulsive disorder at the age of 23 years following isotretinoin treatment for acne (10–20 mg/day) since the age of 16 years. Although standard treatment for obsessive-compulsive disorder caused mood swings, the combination of fluvoxamine 300 mg/day and olanzapine 15 mg/day significantly improves the clinical picture. Although rare, severe adulthood psychiatric complications may occur following isotretinoin treatment, requiring management which is individually tailored to the patient.

Keywords: isotretinoin, obsessive-compulsive disorder, olanzapine, fluvoxamine, treatment

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