Back to Journals » Journal of Asthma and Allergy » Volume 3

Nocturnal thoracoabdominal asynchrony in house dust mite-sensitive nonhuman primates

Authors Wang X, Reece S, Olmstead, Wardle R, Scott V

Published 28 July 2010 Volume 2010:3 Pages 75—86

DOI https://doi.org/10.2147/JAA.S11781

Review by Single-blind

Peer reviewer comments 4


XiaoJia Wang, Shaun Reece, Stephen Olmstead, Robert L Wardle, Michael R Van Scott

Department of Physiology, East Carolina University, Greenville, North Carolina, USA

Abstract: Nocturnal bronchoconstriction is a common symptom of asthma in humans, but is poorly documented in animal models. Thoracoabdominal asynchrony (TAA) is a noninvasive clinical indication of airway obstruction. In this study, respiratory inductive plethysmography (RIP) was used to document nocturnal TAA in house dust mite (HDM)-sensitive Cynomolgus macaques. Dynamic compliance (Cdyn) and lung resistance (RL) measured in anesthetized ­animals at rest and following exposure to HDM allergen, methacholine, and albuterol were highly ­correlated with three RIP parameters associated with TAA, ie, phase angle of the rib cage and abdomen waveforms (PhAng), baseline effort phase relation (eBPRL) and effort phase relation (ePhRL). Twenty-one allergic subjects were challenged with HDM early in the morning, and eBPRL and ePhRL were monitored for 20 hours after provocation. Fifteen of the allergic subjects exhibited gradual increases in eBPRL and ePhRL between midnight and 6 am, with peak activity at 4 am. However, as in humans, this nocturnal response was highly variable both between subjects and within subjects over time. The results document that TAA in this nonhuman primate model of asthma is highly correlated with Cdyn and RL, and demonstrate that animals exhibiting acute responses to allergen exposure during the day also exhibit nocturnal TAA.

Keywords: nocturnal asthma, late phase asthmatic response, respiratory inductive plethysmography

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]