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Newer agents for Helicobacter pylori eradication

Authors Fiorini G, Zullo A, Gatta L, Castelli V, Ricci C, Cassol F, Vaira D

Received 9 February 2012

Accepted for publication 10 March 2012

Published 18 June 2012 Volume 2012:5 Pages 109—112

DOI https://doi.org/10.2147/CEG.S25422

Review by Single anonymous peer review

Peer reviewer comments 3


Giulia Fiorini,1 Angelo Zullo,2 Luigi Gatta,3 Valentina Castelli,1 Chiara Ricci,3 Francesca Cassol,4 Dino Vaira1

1Department of Clinical Medicine, University of Bologna, Italy; 2Gastroenterology and Digestive Endoscopy, 'Nuovo Regina Margherita' Hospital, Rome, Italy; 3Versilia Hospital, Lido di Camaiore, Italy; 4School of Gastroenterology, University of Ferrera, Ferrera, Italy

Abstract: Helicobacter pylori infection remains widespread internationally, with a definite morbidity and mortality. The efficacy of standard 7–14 day triple therapies is decreasing, mainly due to increasing primary bacterial resistance to antibiotics. Currently, the most effective treatments are either the sequential regimen or the concomitant therapy. Different patents have been registered showing high bactericidal effects in vitro, some of which are active against clarithromycin- and metronidazole-resistant strains, even at low pH values. Among these novel molecules, benzimidazole-derivatives, polycyclic compounds, pyloricidin, and arylthiazole analogues seem to be the more promising. The identification of essential genes for either bacterial colonization or growth represents a route for potential target therapies in the near future.

Keywords: Helicobacter pylori therapy, new antibiotic agents

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