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Retinopathy associated with interferon therapy in patients with hepatitis C virus

Authors Mohamed, Eed

Received 31 March 2012

Accepted for publication 24 May 2012

Published 20 August 2012 Volume 2012:6 Pages 1341—1345

DOI https://doi.org/10.2147/OPTH.S32469

Review by Single-blind

Peer reviewer comments 2


Mahmoud Abd El-Badie Mohamed,1 Khaled Abd-El azeem Eed2

1
Ophthalmology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt; 2Gastroentrology and Hepatology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt

Purpose: To evaluate retinopathy associated with interferon therapy in patients with chronic hepatitis C.
Methods: One hundred patients with chronic hepatitis C undergoing interferon therapy were examined for the presence of cotton wool spots, retinal hemorrhages, cystoid macular edema, capillary non-perfusion, and arteriolar occlusion. Complete ophthalmological examination including indirect ophthalmoscopic fundus examination was carried out for all patients and colored fundus photography and fluorescein angiography were carried out for the patients with positive fundus findings. The follow-up period was 9 months.
Results: Sixteen percent of patients developed retinopathy in the form of cotton wool spots, retinal hemorrhages, cystoid macular edema, and capillary non-perfusion.
Conclusion: Interferon therapy can lead to retinopathy which is mostly reversible and dose related. Periodic fundoscopic examinations help in early detection and prevent progression to permanent visual loss.

Keywords: retinopathy, interferon, hepatitis C, complications

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