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Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease

Authors Fonseca-Santos B, Gremião MP, Chorilli M

Received 22 April 2015

Accepted for publication 16 May 2015

Published 4 August 2015 Volume 2015:10(1) Pages 4981—5003

DOI https://doi.org/10.2147/IJN.S87148

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 3

Editor who approved publication: Professor Carlos Rinaldi

Bruno Fonseca-Santos, Maria Palmira Daflon Gremião, Marlus Chorilli

Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil

Abstract: Alzheimer’s disease is a neurological disorder that results in cognitive and behavioral impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs, often fail due to their poor solubility, lower bioavailability, and ineffective ability to cross the blood–brain barrier. Nanotechnological treatment methods, which involve the design, characterization, production, and application of nanoscale drug delivery systems, have been employed to optimize therapeutics. These nanotechnologies include polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, and liquid crystals. Each of these are promising tools for the delivery of therapeutic devices to the brain via various routes of administration, particularly the intranasal route. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease.

Keywords: Alzheimer’s disease, polymeric nanoparticles, solid lipid nanocarriers, microemulsions, liquid crystals, targeted delivery, nose-to-brain

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