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Nanoparticles of barium induce apoptosis in human phagocytes

Authors Mores L, França EL, Silva NA, Suchara EA, Honorio-França AC

Received 13 June 2015

Accepted for publication 1 September 2015

Published 28 September 2015 Volume 2015:10(1) Pages 6021—6026

DOI https://doi.org/10.2147/IJN.S90382

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Farooq Shiekh

Peer reviewer comments 3

Editor who approved publication: Professor Carlos Rinaldi

Luana Mores, Eduardo Luzia França, Núbia Andrade Silva, Eliane Aparecida Suchara, Adenilda Cristina Honorio-França

Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, Mato Grosso, Brazil

Purpose: Nutrients and immunological factors of breast milk are essential for newborn growth and the development of their immune system, but this secretion can contain organic and inorganic toxins such as barium. Colostrum contamination with barium is an important issue to investigate because this naturally occurring element is also associated with human activity and industrial pollution. The study evaluated the administration of barium nanoparticles to colostrum, assessing the viability and functional activity of colostral mononuclear phagocytes.
Methods: Colostrum was collected from 24 clinically healthy women (aged 18–35 years). Cell viability, superoxide release, intracellular Ca2+ release, and phagocyte apoptosis were analyzed in the samples.
Results: Treatment with barium lowered mononuclear phagocyte viability, increased superoxide release, and reduced intracellular calcium release. In addition, barium increased cell death by apoptosis.
Conclusion: These data suggest that nanoparticles of barium in colostrum are toxic to cells, showing the importance of avoiding exposure to this element.

Keywords: barium chloride, colostrum, immune cells, intracellular Ca2+, immunotoxicology

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