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Nanomedicine applications in the treatment of breast cancer: current state of the art

Authors Wu D, Si M, Xue H, Wong HL

Received 25 May 2017

Accepted for publication 6 July 2017

Published 16 August 2017 Volume 2017:12 Pages 5879—5892

DOI https://doi.org/10.2147/IJN.S123437

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Thomas Webster


Di Wu, Mengjie Si, Hui-Yi Xue, Ho-Lun Wong

Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia, PA, USA

Abstract: Breast cancer is the most common malignant disease in women worldwide, but the current drug therapy is far from optimal as indicated by the high death rate of breast cancer patients. Nanomedicine is a promising alternative for breast cancer treatment. Nanomedicine products such as Doxil® and Abraxane® have already been extensively used for breast cancer adjuvant therapy with favorable clinical outcomes. However, these products were originally designed for generic anticancer purpose and not specifically for breast cancer treatment. With better understanding of the molecular biology of breast cancer, a number of novel promising nanotherapeutic strategies and devices have been developed in recent years. In this review, we will first give an overview of the current breast cancer treatment and the updated status of nanomedicine use in clinical setting, then discuss the latest important trends in designing breast cancer nanomedicine, including passive and active cancer cell targeting, breast cancer stem cell targeting, tumor microenvironment-based nanotherapy and combination nanotherapy of drug-resistant breast cancer. Researchers may get insight from these strategies to design and develop nanomedicine that is more tailored for breast cancer to achieve further improvements in cancer specificity, antitumorigenic effect, antimetastasis effect and drug resistance reversal effect.

Keywords:
nanomedicine, breast cancer, targeted delivery, drug therapy, drug resistance, tumor microenvironment
 

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