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Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review

Authors Kamudzandu M, Roach P, Fricker RA, Yang Y

Received 26 July 2015

Accepted for publication 9 October 2015

Published 2 December 2015 Volume 2015:3 Pages 123—131

DOI https://doi.org/10.2147/JN.S70337

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Professor Hooshang Saberi

Peer reviewer comments 3

Editor who approved publication: Dr Hongyun Huang

Munyaradzi Kamudzandu, Paul Roach, Rosemary A Fricker, Ying Yang

Institute for Science and Technology in Medicine, School of Medicine, Keele University, Stoke-on-Trent, UK

Abstract: Restoration of function following damage to the central nervous system (CNS) is severely restricted by several factors. These include the hindrance of axonal regeneration imposed by glial scars resulting from inflammatory response to damage, and limited axonal outgrowth toward target tissue. Strategies for promoting CNS functional regeneration include the use of nanotechnology. Due to their structural similarity, synthetic nanofibers could play an important role in regeneration of CNS neural tissue toward restoration of function following injury. Two-dimensional nanofibrous scaffolds have been used to provide contact guidance for developing brain and spinal cord neurites, particularly from neurons cultured in vitro. Three-dimensional nanofibrous scaffolds have been used, both in vitro and in vivo, for creating cell adhesion permissive milieu, in addition to contact guidance or structural bridges for axons, to control reconnection in brain and spinal cord injury models. It is postulated that nanofibrous scaffolds made from biodegradable and biocompatible materials can become powerful structural bridges for both guiding the outgrowth of neurites and rebuilding glial circuitry over the “lesion gaps” resulting from injury in the CNS.

Keywords: scaffold, nanofibrous scaffold, CNS, regeneration, alignment

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