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Myopathy due to HMGCR antibodies in adult mimicking muscular dystrophy associated with cancer and statin exposure – narrative review of the literature – case report

Authors Carvalho AAS, Silva VG, Zanoteli E, Feder D

Received 18 January 2018

Accepted for publication 9 March 2018

Published 14 May 2018 Volume 2018:14 Pages 903—907

DOI https://doi.org/10.2147/TCRM.S162931

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Alzira Alves de Siqueira Carvalho,1 Vinicius Gomes da Silva,1 Edmar Zanoteli,2 David Feder3

1Laboratory of Neuromuscular Disease, Department of Neurosciences, School of Medicine of ABC, Santo André, São Paulo, Brazil; 2Department of Neurology, School of Medicine of University of São Paulo, São Paulo, Brazil; 3Department of Pharmacology, School of Medicine of ABC, Santo André, São Paulo, Brazil

Abstract: Necrotizing autoimmune myopathy is characterized by predominant muscle fiber necrosis and regeneration with little or no inflammation. We describe a 58-year-old woman with previous breast cancer and statin use who complained of rapidly progressive weakness of lower limbs without pain, making walking, running and climbing stairs difficult. The creatine kinase level was 2,843 U/L, and muscle biopsy showed a dystrophic pattern. The genetic test for muscular dystrophies was negative and for anti-3-hydroxy-3-methylglutaryl coenzyme A reductase was positive. Intravenous immunoglobulin was administered, which showed mild improvement. Unfortunately, she took a step and collapsed to the floor, which led to the fracture of right femur delaying her improvement. The diagnosis of necrotizing autoimmune myopathy is sometimes delayed due to the atypical pathologic findings on muscle biopsy. As the disease is a severe condition, prompt recognition can lead to a successful outcome. We advise to consider this entity as a differential diagnosis among muscular dystrophies.

Keywords: necrotizing autoimmune myopathy, HMGCR antibody, muscular dystrophy, cancer, statin

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