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Molecular guided therapy for advanced pancreatic cancer patients with PI3K activated mutation: vision or illusion?

Authors Gazzah A, Gonzales D, Levy A, Bahleda R, Ducreux M, Lacroix L, Soria J

Received 25 September 2012

Accepted for publication 25 October 2012

Published 20 February 2013 Volume 2013:6 Pages 95—97

DOI https://doi.org/10.2147/OTT.S38520

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

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Anas Gazzah,1 Daniel Barrios Gonzales,1 Antonin Levy,1 Rastislav Bahleda,1 Michel Ducreux,2 Ludovic Lacroix,3 Jean Charles Soria1

1SITEP (Service des Innovations Therapeutiques Précoces), Department of Medicine, Institut Gustave Roussy, Paris XI University, Villejuif, France; 2Department of Medicine, Institut Gustave Roussy, Paris XI University, Villejuif, France; 3Department of Biology, Institut Gustave Roussy, Paris XI University, Villejuif, France

Abstract: Despite a modern validated regimen of chemotherapy, advanced pancreatic adenocarcinoma remains the fourth most common cause of cancer-related death worldwide. The phosphoinositide 3-kinase pathway (PI3K)/Akt/mammalian target of rapamycin (mTOR) is a major signaling pathway that may be activated in advanced pancreatic cancer. To highlight the potential interest of this targetable pathway in selected advanced pancreatic cancer patients, we report herein a patient with an activated PI3K mutation who was treated in a phase I trial evaluating a treatment combination including an mTOR inhibitor.

Keywords: pancreatic cancer, PI3K, targeted therapy, molecular profiling

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