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Molecular docking studies on the activity of naturally occurring pyranochalcones on the transcriptional regulator enzyme of Pseudomonas putida

Authors Paul SB, Choudhury S

Published 29 June 2010 Volume 2010:2 Pages 61—66


Review by Single-blind

Peer reviewer comments 2

Satya B Paul1, Sudip Choudhury2

1Department of Chemistry, Assam University, Silchar-788011, Assam, India; 2Department of Chemistry, Gurucharan College, Silchar-788004, Assam, India

Abstract: The paper reports the in-silico docking results of 10 naturally occurring pyranochalcones on the transcriptional regulator (TtgR) enzyme, which is a key efflux pump TtgABC operon repressor in the Gram-negative bacteria Pseudomonas putida (DOT-T1E strain) as the receptor. TtgR is a multidrug-binding protein and regulates one of the key mechanisms of its antibiotic resistance by active extrusion of toxic compounds through the membrane-bound efflux pumps. Although the bacteria exhibits resistance against a number of antibiotics, one natural pyranochalcone Pongachalcone I has been reported to be active against it. The presence of alkoxy moiety in the aromatic side unit of the pyranochalcones seems to be instrumental in binding
Keywords: TtgR, docking, in-silico, antibiotic resistance

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