Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Modification of paclitaxel-loaded solid lipid nanoparticles with 2-hydroxypropyl-β-cyclodextrin enhances absorption and reduces nephrotoxicity associated with intravenous injection

Authors Baek JS, Kim JH, Park JS, Cho CW

Received 12 April 2015

Accepted for publication 22 July 2015

Published 26 August 2015 Volume 2015:10(1) Pages 5397—5405

DOI https://doi.org/10.2147/IJN.S86474

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Carlos Rinaldi

Jong-Suep Baek,* Ju-Heon Kim,* Jeong-Sook Park, Cheong-Weon Cho

College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, South Korea

*These authors contributed equally to this work

Background: Paclitaxel (PTX) solid lipid nanoparticles (SLNs) modified with 2-hydroxypropyl-β-cyclodextrin (HPCD) were evaluated for their ability to enhance PTX absorption and reduce the nephrotoxicity accompanying intravenous administration.
Methods: PTX-loaded SLNs (PS) and PTX-loaded SLNs modified using HPCD (PSC) were prepared by hot-melted sonication. The anticancer activity of PSC was evaluated in MCF-7 cells, and confocal microscopy was used to quantify the cellular uptake. The pharmacokinetic profiles of PTX released from PSC after intravenous administration were studied in rats. Furthermore, kidney toxicity was determined by measuring the kidney size and plasma creatinine level.
Results: PSC were successfully prepared by hot-melted sonication and had smaller diameters than PS. PSC exhibited improved anticancer activity and cellular uptake in MCF-7 cells. Furthermore, PSC showed higher bioavailability in rats after intravenous administration than PTX solution; however, no significant differences in kidney toxicity were observed.
Conclusion: Based on these results, PSC could be considered as a potential therapeutic PTX delivery system for breast cancer with low renal toxicity.

Keywords: paclitaxel, solid lipid nanoparticles, 2-hydroxypropyl-β-cyclodextrin, bioavailability, nephrotoxicity

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Preparation and evaluation of polymeric microparticulates for improving cellular uptake of gemcitabine

Lim JH, You SK, Baek JS, Hwang CJ, Na YG, Shin SC, Cho CW

International Journal of Nanomedicine 2012, 7:2307-2314

Published Date: 7 May 2012

Practical preparation procedures for docetaxel-loaded nanoparticles using polylactic acid-co-glycolic acid

Keum CG, Noh YW, Baek JS, Lim JH, Hwang CJ, Na YG, Shin SC, Cho CW

International Journal of Nanomedicine 2011, 6:2225-2234

Published Date: 7 October 2011

Readers of this article also read:

Liquid crystal precursor mucoadhesive system as a strategy to improve the prophylactic action of Syngonanthus nitens (Bong.) Ruhland against infection by Candida krusei

dos Santos Ramos MA, Calixto G, de Toledo LG, Bonifácio BV, dos Santos LC, de Almeida MT, Chorilli M, Bauab TM

International Journal of Nanomedicine 2015, 10:7455-7466

Published Date: 16 December 2015

Enhancement of encapsulation efficiency of nanoemulsion-containing aripiprazole for the treatment of schizophrenia using mixture experimental design

Fard Masoumi HR, Basri M, Sarah Samiun W, Izadiyan Z, Lim CJ

International Journal of Nanomedicine 2015, 10:6469-6476

Published Date: 13 October 2015

Para amino benzoic acid-derived self-assembled biocompatible nanoparticles for efficient delivery of siRNA

Reddy TL, Krishnarao PS, Rao GK, Bhimireddy E, Venkateswarlu P, Mohapatra DK, Yadav JS, Bhadra U, Pal Bhadra M

International Journal of Nanomedicine 2015, 10:6411-6424

Published Date: 12 October 2015

Preparation, characterization, and safety evaluation of poly(lactide-co-glycolide) nanoparticles for protein delivery into macrophages

Guedj AS, Kell AJ, Barnes M, Stals S, Gonçalves D, Girard D, Lavigne C

International Journal of Nanomedicine 2015, 10:5965-5979

Published Date: 23 September 2015

Different patterns of nuclear and mitochondrial penetration by the G3 PAMAM dendrimer and its biotin–pyridoxal bioconjugate BC-PAMAM in normal and cancer cells in vitro

Uram Ł, Szuster M, Filipowicz A, Gargasz K, Wołowiec S, Wałajtys-Rode E

International Journal of Nanomedicine 2015, 10:5647-5661

Published Date: 4 September 2015

Niosomal carriers enhance oral bioavailability of carvedilol: effects of bile salt-enriched vesicles and carrier surface charge 

Arzani G, Haeri A, Daeihamed M, Bakhtiari-Kaboutaraki H, Dadashzadeh S

International Journal of Nanomedicine 2015, 10:4797-4813

Published Date: 29 July 2015