Back to Journals » Research and Reports in Biology » Volume 6

Mitochondrial dysfunction in breast cancer

Authors Riar AK, Kenny TC, Takabatake Y, Papa L, Germain D

Received 22 April 2015

Accepted for publication 9 July 2015

Published 11 September 2015 Volume 2015:6 Pages 137—145

DOI https://doi.org/10.2147/RRB.S62507

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Professor Zvi Kelman

Amanjot Kaur Riar,* Timothy C Kenny,* Yukie Takabatake,* Luena Papa, Doris Germain

Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, USA

*These authors have contributed equally to this work

Abstract: The reprogramming of the mitochondria of cancer cells is essential for their growth. However, such reprogramming leads to the increased formation of reactive oxygen species, which can lead to damage to the organelle. This review summarizes the mechanisms that protect the mitochondrial network against oxidative stress. Further, since several transcription factors have now been linked to the mitochondrial unfolded protein response (UPRmt) and regulate the expression of one or more genes involved in these "mito-protective" mechanisms, the UPRmt is a prime candidate to coordinate the maintenance of the integrity of the mitochondria under oxidative stress conditions.

Keywords: mitochondrial unfolded protein response (UPRmt), mitochondrial DNA, SOD2, reactive oxygen species, breast cancer, mitomiRs, mitochondrial protein quality controls

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

The clinical analysis of acute pancreatitis in colorectal cancer patients undergoing chemotherapy after operation

Ji YL, Han Z, Shao LM, Li YL, Zhao L, Zhao YH

OncoTargets and Therapy 2015, 8:2527-2533

Published Date: 11 September 2015

Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials

Van Heertum RL, Scarimbolo R, Ford R, Berdougo E, O’Neal M

Drug Design, Development and Therapy 2015, 9:5215-5223

Published Date: 11 September 2015

Targeting autophagy in cancer management – strategies and developments

Ozpolat B, Benbrook DM

Cancer Management and Research 2015, 7:291-299

Published Date: 11 September 2015

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010