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Minimally invasive devices for treating lower urinary tract symptoms in benign prostate hyperplasia: technology update

Authors Aoun F, Marcelis Q, Roumeguère T

Received 1 May 2015

Accepted for publication 19 June 2015

Published 19 August 2015 Volume 2015:7 Pages 125—136

DOI https://doi.org/10.2147/RRU.S55340

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Jan Colli


Fouad Aoun1, Quentin Marcelis,1,2 Thierry Roumeguère,2

1Department of Urology, Jules Bordet Institute, 2Department of Urology, Erasme Hospital, University Clinics of Brussels, Université Libre de Bruxelles, Brussels, Belgium

Abstract: Benign prostatic hyperplasia (BPH) represents a spectrum of related lower urinary tract symptoms (LUTS). The cost of currently recommended medications and the discontinuation rate due to side effects are significant drawbacks limiting their long-term use in clinical practice. Interventional procedures, considered as the definitive treatment for BPH, carry a significant risk of treatment-related complications in frail patients. These issues have contributed to the emergence of new approaches as alternative options to standard therapies. This paper reviews the recent literature regarding the experimental treatments under investigation and presents the currently available experimental devices and techniques used under local anesthesia for the treatment of LUTS/BPH in the vast majority of cases. Devices for delivery of thermal treatment (microwaves, radiofrequency, high-intensity focused ultrasound, and the Rezum system), mechanical devices (prostatic stent and urethral lift), fractionation of prostatic tissue (histotripsy and aquablation), prostate artery embolization, and intraprostatic drugs are discussed. Evidence for the safety, tolerability, and efficacy of these “minimally invasive procedures” is analyzed.

Keywords: lower urinary tract symptoms (LUTS), benign prostatic hyperplasia (BPH), minimally invasive therapies, new approaches, experimental therapy

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