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Metalloproteinases in Inflammatory Bowel Diseases

Authors Marônek M, Marafini I, Gardlík R, Link R, Troncone E, Monteleone G

Received 5 February 2021

Accepted for publication 9 March 2021

Published 23 March 2021 Volume 2021:14 Pages 1029—1041

DOI https://doi.org/10.2147/JIR.S288280

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Ning Quan


Martin Marônek,1,* Irene Marafini,2,* Roman Gardlík,1 René Link,3 Edoardo Troncone,2 Giovanni Monteleone2

1Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University in Bratislava, Bratislava, 81108, Slovakia; 2Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, 00133, Italy; 3Institute of Experimental Medicine, Faculty of Medicine, University of Pavol Jozef Šafárik, Košice, 040 11, Slovakia

*These authors contributed equally to this work

Correspondence: Giovanni Monteleone
Dipartimento di Medicina dei Sistemi, Università di Roma “Tor Vergata”, Via Montpellier 1, Rome, 00133, Italy
Tel +39 06 20903702
Fax +39 06 72596391
Email [email protected]

Abstract: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract, encompassing two main disorders: Crohn’s disease (CD) and ulcerative colitis (UC). In both these pathologies, excessive and local immune response against luminal antigens promotes a pathological process leading to various degrees of gut damage. Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. In physiological conditions, MMPs are produced at very low level and generally in the latent form and are involved in the normal tissue turnover. Their function is inhibited by tissue inhibitors of metalloproteinases (TIMPs). However, in inflamed tissue of IBD patients, MMPs are produced in excess and/or the activity of TIMPs is not sufficient to block MMPs, thereby making a major contribution to the IBD-related mucosal degradation. In this review, we summarize the available evidence on the expression and role of MMPs in IBD.

Keywords: tissue inhibitor of metalloproteinases, Crohn’s disease, ulcerative colitis, intestinal inflammation

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