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Metabolic signals in sleep regulation: recent insights

Authors Shukla C, Basheer R

Received 2 July 2015

Accepted for publication 19 October 2015

Published 5 January 2016 Volume 2016:8 Pages 9—20

DOI https://doi.org/10.2147/NSS.S62365

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Steven A Shea


Charu Shukla, Radhika Basheer

Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, West Roxbury, MA, USA

Abstract: Sleep and energy balance are essential for health. The two processes act in concert to regulate central and peripheral homeostasis. During sleep, energy is conserved due to suspended activity, movement, and sensory responses, and is redirected to restore and replenish proteins and their assemblies into cellular structures. During wakefulness, various energy-demanding activities lead to hunger. Thus, hunger promotes arousal, and subsequent feeding, followed by satiety that promotes sleep via changes in neuroendocrine or neuropeptide signals. These signals overlap with circuits of sleep-wakefulness, feeding, and energy expenditure. Here, we will briefly review the literature that describes the interplay between the circadian system, sleep-wake, and feeding-fasting cycles that are needed to maintain energy balance and a healthy metabolic profile. In doing so, we describe the neuroendocrine, hormonal/peptide signals that integrate sleep and feeding behavior with energy metabolism.

Keywords: sleep, energy balance, hypothalamus, metabolism, homeostasis

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