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Mesalazine-induced eosinophilic pneumonia with bone marrow infiltration: a case report and literature review

Authors Zhang Y, Luo L, Wang X, Liu X, Wang X, Ding Y

Received 23 February 2016

Accepted for publication 13 April 2016

Published 14 June 2016 Volume 2016:12 Pages 975—981

DOI https://doi.org/10.2147/TCRM.S107012

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 2

Editor who approved publication: Professor Deyun Wang

Yunjian Zhang,1 Ling Luo,1 Xiaofang Wang,1 Xiaoyang Liu,1 Xiaoyan Wang,1 Yi Ding2

1Division of Pulmonary and Critical Care Medicine, Department of Medicine, 2Department of Pathology, Jishuitan Hospital, Fourth Medical College of Peking University, Beijing, People’s Republic of China

Abstract: Mesalazine-induced eosinophilic pneumonia has been rarely reported. We reported a case of mesalazine-induced eosinophilic pneumonia in a 56-year-old female who took mesalazine without a prescription for suspected ulcerative colitis. She had an elevated eosinophil count in peripheral blood and bronchoalveolar lavage fluid. Eosinophil infiltration was also noted in bone marrow aspirates. Chest radiograph and computed tomography demonstrated bilateral upper lung predominant infiltrates and spirometry showed a restrictive ventilatory defect with a reduced diffusion capacity. The patient recovered after cessation of mesalazine therapy. Mesalazine-induced lung damage should be considered in patients who develop unexplained respiratory symptoms while taking this agent.

Keywords: mesalazine, pneumonia, eosinophil, colitis

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