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Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir

Authors Neely M, Kovacs A

Published 31 July 2009 Volume 2009:5 Pages 595—615

DOI https://doi.org/10.2147/TCRM.S4595

Review by Single-blind

Peer reviewer comments 2


Michael Neely, Andrea Kovacs

University of Southern California Keck School of Medicine, Department of Pediatrics, Division of infectious Diseases, Los Angeles, CA, USA

Abstract: Darunavir is currently the most recently approved HIV-1 protease inhibitor. It is approved for twice-daily dosing with ritonavir in treatment-experienced patients as young as 6 years of age and is available in numerous pill strengths. Emergence of darunavir-specific mutations is generally slow; therefore it can retain activity against viral strains that are resistant to other protease inhibitors, including tipranavir. Darunavir pharmacokinetics, clinical efficacy, resistance mutations and pharmacodynamics, and adverse effects are reviewed here. Substantial data support its use as a potent, well-tolerated option for salvage therapy in highly treatment experienced children and adolescents.

Keywords: darunavir, protease inhibitors, treatment, child, adolescent

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