Back to Journals » Clinical Interventions in Aging » Volume 4

Management of osteoporosis in the aging male: Focus on zoledronic acid

Authors Piper P, Gruntmanis U

Published 17 June 2009 Volume 2009:4 Pages 289—303


Review by Single-blind

Peer reviewer comments 3

Paul K Piper Jr1, Ugis Gruntmanis1,2

1Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, TX USA; 2North Texas Veterans Affairs Medical Center, Dallas, TX USA

Abstract: Osteoporosis in the aging male remains an important yet under-recognized and undertreated disease. Current US estimates indicate that over 14 million men have osteoporosis or low bone mass, and men suffer approximately 500,000 osteoporotic fractures each year. Men experience fewer osteoporotic fractures than women but have higher mortality after fracture. Bisphosphonates are potent antiresorptive agents that inhibit osteoclast activity, suppress in vivo markers of bone turnover, increase bone mineral density, decrease fractures, and improve survival in men with osteoporosis. Intravenous zoledronic acid may be a preferable alternative to oral bisphosphonate therapy in patients with cognitive dysfunction, the inability to sit upright, or significant gastrointestinal pathology. Zoledronic acid (Reclast) is approved in the US as an annual 5 mg intravenous infusion to treat osteoporosis in men. The zoledronic acid (Zometa) 4 mg intravenous dose has been studied in the prevention of bone loss associated with androgen deprivation therapy.

Keywords: male osteoporosis, bisphosphonates, zoledronic acid

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]