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Management of hereditary angioedema in pregnant women: a review

Authors Caballero T, Canabal J, Rivero-Paparoni D, Cabañas R

Received 3 February 2014

Accepted for publication 20 June 2014

Published 9 September 2014 Volume 2014:6 Pages 839—848

DOI https://doi.org/10.2147/IJWH.S46460

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3


Teresa Caballero,1,2 Julio Canabal,1 Daniela Rivero-Paparoni,1 Rosario Cabañas1

1Hospital La Paz Institute for Health Research, (IdiPaz) 2Biomedical Research Network on Rare Diseases-U754 (CIBERER), Madrid, Spain

Abstract: Three types of hereditary angioedema (HAE) have been described: two are due to C1 inhibitor (C1-INH) deficiency (C1-INH-HAE types I and II) and one is characterized by normal C1-INH (nC1-INH-HAE). The management of pregnancy in patients with HAE is often a clinical challenge owing to potential worsening of the disease in relation to the physiological increase in estrogens and the limited treatment options. This review addresses the potential influence of pregnancy on the clinical severity of hereditary angioedema and the management of this disease during pregnancy with currently available treatments.

Keywords: hereditary angioedema, pregnancy, female, treatment, C1 inhibitor concentrate, tranexamic acid

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