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Maedi-Visna virus: current perspectives

Authors Gomez-Lucia E, Barquero N, Domenech A

Received 28 December 2017

Accepted for publication 8 March 2018

Published 21 May 2018 Volume 2018:9 Pages 11—21

DOI https://doi.org/10.2147/VMRR.S136705

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Professor Young Lyoo


Esperanza Gomez-Lucia, Nuria Barquero, Ana Domenech

Department of Animal Health, Faculty of Veterinary Medicine, Complutense University, Madrid, Spain

Abstract: Maedi-Visna virus (MVV) and caprine arthritis-encephalitis virus are commonly known as small ruminant lentiviruses (SRLVs) due to their genetic, structural, and pathogenic similarities. They produce lifelong lasting infections in their hosts, which are characterized by slow progression till overt disease happens. There are four major clinical forms derived from a chronic inflammatory response due to the constant low grade production of viruses from monocyte-derived macrophages: respiratory (caused by interstitial pneumonia), mammary (which may produce a decrease in milk production due to subclinical mastitis), joint (characterized by lameness), and neurological (characterized by chronic nonpurulent meningoencephalomyelitis). There are three levels which try to eliminate the virus: cellular, body, and the flock level. However, SRLVs have ways to counteract these defenses. This review examines some of them.

Keywords: small ruminant lentivirus, molecular biology, immune response, genetic resistance

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