Lower extremity amputation in peripheral artery disease: improving patient outcomes
Aparna Swaminathan,1 Sreekanth Vemulapalli,1,2 Manesh R Patel,1,2 W Schuyler Jones1,2
1Department of Medicine, Duke University Medical Center, Durham, NC, USA; 2Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
Abstract: Peripheral artery disease affects over eight million Americans and is associated with an increased risk of mortality, cardiovascular disease, functional limitation, and limb loss. In its most severe form, critical limb ischemia, patients are often treated with lower extremity (LE) amputation (LEA), although the overall incidence of LEA is declining. In the US, there is significant geographic variation in the performing of major LEA. The rate of death after major LEA in the US is approximately 48% at 1 year and 71% at 3 years. Despite this significant morbidity and mortality, the use of diagnostic testing (both noninvasive and invasive testing) in the year prior to LEA is low and varies based on patient, provider, and regional factors. In this review we discuss the significance of LEA and methods to reduce its occurrence. These methods include improved recognition of the risk factors for LEA by clinicians and patients, strong advocacy for noninvasive and/or invasive imaging prior to LEA, improved endovascular revascularization techniques, and novel therapies.
Keywords: peripheral artery disease, lower extremity amputation, mortality
Lower extremity peripheral artery disease (LE PAD) is a prevalent condition in the US, affecting approximately 8 million Americans.1,2 Although about 50% of patients with PAD are asymptomatic (Rutherford classification 0; Table 1), they are at an increased risk of mortality, myocardial infarction (MI), and stroke.3–6 The most frequent clinical manifestation of PAD is intermittent claudication (Rutherford classification 1–3; Table 1), which is defined as leg pain with exertion that improves with rest. Patients with intermittent claudication suffer from significant functional limitations in their daily activities, and over a 5-year period approximately 5% of these patients progress to LE amputation (LEA).7,8 The most severe manifestation of PAD is critical limb ischemia (CLI) (Rutherford classification 4–6; Table 1), which is associated with a 1-year mortality rate of 20% and a 1-year limb loss rate of 20%.1,9 Despite the significant health burden it poses,10 public knowledge is poor, and underdiagnosis and undertreatment of CLI are frequent until limb symptoms become severe.11
Table 1 Peripheral artery disease symptom classification: Fontaine stages and Rutherford categories
Once PAD is diagnosed, guidelines recommend treatment with cardioprotective medications (such as an antiplatelet agent and statin), exercise training, and risk factor modification (Figure 1).12 Many patients remain symptomatic despite these measures and undergo LE revascularization procedures to improve blood flow, minimize symptoms, and improve quality of life. Over the past two decades, surgical intervention (LE bypass and/or endarterectomy) has largely been supplanted by endovascular intervention (atherectomy, angioplasty, and/or stenting) as the most common revascularization choice for patients with PAD. Although the complication rate and overall morbidity associated with endovascular intervention are lower when compared with surgical revascularization, the durability and need for repeat intervention remain a significant challenge for endovascular treatment. LEA is generally reserved for situations where medical or revascularization options do not exist, when significant tissue loss has occurred, or when optimal medical therapy and/or revascularization fail. It is often considered as a last resort because it is associated with substantially higher morbidity, mortality, and health care costs.13,14
Figure 1 Conceptual framework of treatment of patients with peripheral artery disease (PAD).
Multiple groups have addressed the importance of preventing LEA. However, it is important to note that standardized definitions for LEA vary in the literature. The National Institute for Health and Clinical Excellence (NICE) guidelines focus on amputation at different levels of the LE (eg, toe, metatarsal, below the knee amputation [BKA], and above the knee amputation [AKA]).15 The Peripheral Academic Research Consortium (PARC), a consortium of academic experts and representatives from industry and the US Food and Drug Administration, has also attempted to standardize definitions of LEA (submitted; unpublished). A minor amputation is defined as any procedure that results in amputation below the ankle, including the foot or toe(s). A major amputation is defined as any procedure that results in amputation at the level of the ankle or above, and is further divided based on its location in relation to the knee. BKA is an amputation affecting the tibia at any point below the knee and above the ankle. AKA is an amputation above the knee, affecting the femur at any level.
The rates of LEA in the US are unacceptably high. A recent analysis of US Medicare data from 2000 to 2008 found that out of approximately three million patients hospitalized with PAD, 186,338 underwent major LEA during that time (6.8%).16,17 The patients who underwent major LEA had mortality rates that were nearly twice as high as those who did not undergo major LEA at 30 days (13.5% versus [vs] 6.9%), 1 year (48.3% vs 24.2%), and 3 years (70.9% vs 43.2%) (Figure 2).16 These striking rates of mortality in patients with PAD, with and without major LEA, highlight the need for programs to improve public awareness and standardize treatment strategies for the prevention of LEA.
Figure 2 Clinical outcomes after lower extremity (LE) amputation. The occurrence of death, myocardial infarction, and stroke in patients hospitalized for peripheral artery disease (PAD) with and without major LE amputation: cumulative incidence rates of all-cause mortality (top panel), myocardial infarction (middle panel), and stroke (bottom panel) after major LE amputation.
Are all amputations equal?
Characteristics of both the patient and the provider can influence the decision to perform an LEA, as well as outcomes following LEA. Patient risk factors that contribute to the decision to perform LEA include the severity of symptoms and the burden and duration of PAD. Some patients with CLI present with rest pain, which is foot and/or digit pain at rest that is relieved with dependency (Rutherford classification 4; Table 1). Other patients with CLI present with tissue loss, ranging from ulceration (Rutherford classification 5; Table 1) to gangrene (Rutherford classification 6; Table 1). LE arterial anatomy is also a factor in performing LEA, although its impact has been poorly studied. Although a simple risk prediction score for arterial anatomy does not exist, a risk score from the Project of Ex-vivo Graft Engineering via Transfection III (PREVENT III) study is a useful tool to predict amputation-free survival prior to revascularization in CLI patients.18 Similar to this PREVENT III risk score, a Medicare report found that compared with patients with PAD who did not undergo LEA, those who underwent LEA were more likely to be male, African American, have diabetes, and have renal disease.16,17 Patient features that were associated with increased mortality after LEA included advanced age, heart failure, renal failure, cancer, and chronic obstructive pulmonary disease.16
One important provider characteristic is geographic location. Review of Medicare data showed significant geographic variation in the rates of LEA across the US (Figure 3).17 This may be due, in part, to a lack of uniform treatment algorithms to determine either the need for LEA or the level of LEA. This is important because AKA has been associated with a significantly higher hazard of death compared with more distal locations (3-year mortality rate of 76.6% for patients undergoing AKA when compared with 63.1% in patients undergoing BKA).16 Goodney et al19 reviewed Medicare claims data of over 18,000 patients to determine the average inpatient cost in the year prior to amputation. They found that this cost varied widely based on geographic region (from $11,077 to $42,613), and higher spending was associated with more revascularization procedures.19 Conclusions from this study about the effects of regional spending on LEA rates are difficult to make, as all patients in this study had an LEA.
Figure 3 Geographic variation of major amputation of the lower extremity.
Although the need for LEA is likely evidence of an elevated cardiovascular risk in these patients rather than the cause of substantial morbidity and mortality, awareness of the dramatically high mortality rate after major LEA serves as a call to action for clinicians, payers, and policy makers. Furthermore, the morbidity rate after LEA is also quite substantial, but it has been inadequately captured in studies. Arriving at a treatment strategy that leads to a reduction in LEA should be the goal of all clinicians caring for patients at risk for limb loss. Unfortunately, the recent American College of Cardiology (ACC)/American Heart Association (AHA) performance measures document for adults with PAD does not address patients at risk for or undergoing major LEA.20 We therefore highlight several approaches that we think may lead to better patient outcomes.
Methods to reduce LEA
The first step to reducing LEA is improved recognition of LE PAD by both patients and clinicians. Timing of presentation of patients with CLI significantly varies, with some presenting with rest pain and others ischemic ulceration or gangrene. The underlying reason for this poor recognition is the public’s lack of awareness of the signs and symptoms of PAD.11 In contrast, patient education of possible symptoms of MI is quite widespread in the US, in part due to the ACC/AHA practice guidelines and patient awareness campaigns that stress its importance.21 Similar to treatment of MI, morbidity and mortality of CLI can be reduced significantly if patients are educated about prevention measures (eg, foot and toenail care) and the need to present for early evaluation if signs or symptoms arise. In response to studies that document lack of patient awareness, the national Peripheral Arterial Disease Coalition, an alliance of over 50 cardiovascular and vascular health professional societies, health advocacy groups, and government agencies, was founded to provide accurate health information to those with or at risk for PAD.
Encouragingly, there has been an overall decline in the rate of LEA from 7,258 per 100,000 patients with PAD in 2000 to 5,790 per 100,000 patients with PAD in 2008.17 Possible explanations for the decreasing rate of LEA include improvements in screening and detection of vascular disease16,22,23 and improvements in endovascular revascularization techniques and other treatments. Along with this decline in the rates of LEA, a concomitant decline in the all-cause mortality rate has also been observed.15
Advocacy for noninvasive and/or invasive imaging prior to LEA
Current decision making around the need for LEA and level of LEA is determined by physician expertise and preference. The threshold to perform LEA is different among various providers, and no uniform treatment algorithm exists. This may help explain some of the geographic variation in rates of LEA and mortality following LEA.16,17 Significant regional differences exist in the intensity of diagnostic angiography, endovascular revascularization, and surgical revascularization in the year preceding LEA.22 Another study found that among the 17,463 Medicare beneficiaries who underwent nontraumatic LEA from 2000 to 2010, only 68.4% underwent some type of arterial testing in the preceding 24 months.24 Of these patients, 47.5% underwent ankle–brachial index measurement, 38.7% duplex ultrasound, 31.1% invasive angiography, 6.7% computed tomographic angiography, and 5.6% magnetic resonance angiography.24 Women, younger patients, and patients living in rural areas were all less likely to receive preamputation arterial testing.24
A standardized approach to imaging prior to LEA may help reduce unnecessary limb loss and identify factors to help guide the decision regarding level of LEA. The NICE 2012 guidelines currently state not to perform major LEA in patients with CLI unless a vascular team has considered all options for revascularization,15 but adherence to this guideline is not commonplace in the US. Furthermore, a consistent care pathway to determine the necessary level of major LEA is needed to preserve ambulatory status and decrease the occurrence of AKA due to extraordinarily high morbidity and mortality. Further research is essential in understanding “best practices” in imaging and preamputation testing prior to LEA.
Improved revascularization techniques
Significant advances in endovascular and surgical technology for PAD have occurred in the past decade, and, at least in the US, there has been a shift from surgical to endovascular revascularization.25 When combined with improved screening and detection methods, the increased use of both surgical and endovascular revascularization in patients with PAD has likely contributed to the decline in LEA rates.26 Examples of advances in endovascular technologies for revascularization that are being examined to improve outcomes in PAD include drug-coated balloons, atherectomy devices, chronic total occlusion recanalization devices, and improvements in stent technology.27–32
More research is necessary to determine the effects of endovascular versus surgical revascularization with regard to enhancing limb preservation. A recent meta-analysis of 23 trials comparing endovascular and surgical revascularization did not find any difference in mortality or LEA in approximately 12,800 patients with CLI.33 The only randomized controlled trial included in this meta-analysis, the Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) study, did not show a difference between endovascular and surgical revascularization.34 However, this study enrolled patients over 10 years ago and did not allow endovascular stent placement in the angioplasty arm.
Novel therapies: cell therapy and gene therapy
Evidence-based treatments for atherosclerosis, such as antiplatelet agents, statins, and risk factor modification, are the mainstay of medical therapy for PAD. None of these therapies, however, directly affects LE blood flow. Over the past decade the use of biologic treatments to induce angiogenesis (ie, protein therapy, gene therapy, and cell therapy) has been investigated for treatment of advanced PAD.35–40 Because of the short half-life of recombinant proteins, current clinical trials have approached the delivery of angiogenic factors through either a cell-based therapy or a gene therapy approach. Several phase II randomized, placebo-controlled gene therapy trials have been promising, though a recent phase III trial of intramuscular nonviral 1 fibroblast growth factor compared with placebo did not demonstrate a reduction in LEA or death.35,39,40 Despite this, therapeutic angiogenesis remains an intriguing option for the future because of a relative ease of administration and the potential to benefit from an autocrine/paracrine effect of the biologic substrates.
Gaps in evidence
There is a dearth of high-quality data available to aid clinical decision making in patients with CLI, a fact confirmed by a recent meta-analysis of 23 studies and the NICE guidelines.15,41 The strength of evidence was rated low or insufficient for most findings in the observational trials. In addition to insufficient evidence to demonstrate a difference between the comparators, most of these studies did not assess functional outcomes, quality of life, or cardiovascular outcomes such as MI, stroke, or cardiovascular death. Furthermore, few studies measured the effect of treatment based on patient subgroups. Focusing on outcomes based on patient-specific factors such as presenting severity (eg, rest pain and tissue loss), comorbid conditions (eg, age, diabetes mellitus, and end-stage renal disease), and anatomic factors will help guide clinical decision making.
One of the biggest barriers to accumulation of knowledge in and across PAD therapies and technologies is the lack of consistent definitions and nomenclature across clinical trials. Additionally, recent clinical trials have used different outcomes, including surrogate end points such as procedural success and vessel patency. In response to the need to develop standard definitions and outcomes for LE PAD, PARC was formed. This group has broad representation from multiple disciplines in academia, industry, and regulatory agencies, and continues to work at accomplishing the aforementioned goals. Alternative data analytical methods, such as global rank end points, have also been proposed for use in trials rather than time to event models or objective performance goals.42 This has the potential to more comprehensively evaluate the effect of a therapy, especially in early phase studies. It creates a hierarchy of end points based on clinical importance a priori, thus allowing for measures such as quality of life to be incorporated.42
An evolution in medical, endovascular, and surgical therapies aimed at improving PAD is underway. With the proliferation of revascularization devices and therapies, there is an increasing need for clarity regarding effectiveness data and the impact on amputations, mortality, MI, stroke, and quality of life. The recent announcement by the National Institutes of Health that funding has been approved for the Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia (BEST) trial (NCT02060630) is a positive step forward, but many more such steps need to be taken. The Patient Centered Outcomes Research Institute and the Institute of Medicine have both identified PAD as a health care priority. More studies that both identify outcomes that are important to patients and measure the effectiveness and safety of pharmaceuticals, biologic agents, and devices in patients at high risk for LEA are necessary.
Moving forward, clinicians and policy makers must continue to devise innovative ways to deliver high-value clinical care to patients with PAD. Although many have proposed quality improvement programs and even public reporting of CLI measures as ways to improve quality of care in PAD patients, a first step must be to better understand “best clinical practices” for patients at risk for CLI and with CLI. The possible unintended consequences of publicly reporting CLI measures and outcomes may be a shift toward the performing of fewer revascularization procedures, especially in the sickest patients who may benefit most from it. This has been observed in the use of primary PCI for ST segment elevation MI patients (ie, fewer revascularization procedures have been performed in regions/states that require public reporting of mortality after PCI).43,44 Ultimately, our goal is to create a system to encourage necessary interventions for those PAD patients who would benefit from them the most.
The authors report no conflicts of interest in this work.
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