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Low STYK1 expression indicates poor prognosis in gastric cancer

Authors Fang J, Wang H, Fang X, Li N, Hu H, Bian M, Yang P

Received 30 July 2018

Accepted for publication 18 October 2018

Published 6 December 2018 Volume 2018:10 Pages 6669—6676

DOI https://doi.org/10.2147/CMAR.S181910

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Professor Nakshatri


Jian Fang,1,* Hao Wang,2,* Xiao Fang,3 Na Li,1 Hailiang Hu,1 Maohong Bian,1 Peng Yang1

1Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China; 2Department of General Surgery and Translational Medicine Center, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi 214002, Jiangsu, China; 3Department of Orthopaedics, Hefei Orthopaedics Hospital, Hefei 230000, Anhui, China

*These authors contributed equally to this work

Background: The expression of serine threonine tyrosine kinase 1 (STYK1), a member of the receptor protein tyrosine kinase (RPTK) family, is abnormal in several cancers. However, the molecular mechanism of STYK1 regulation of gastric cancer (GC) progression is unknown.
Materials and methods: We evaluated STYK1 expression in GC tissues and the corresponding normal tissues. Specimens from 93 patients with GC were examined with immunohistochemical staining. The relationship between STYK1 protein expression and the patients’ clinicopathological features was assessed. Kaplan–Meier and Cox proportional regression analyses were used to evaluate the association between STYK1 expression and survival.
Results: STYK1 expression was decreased in GC tissues. Low STYK1 expression was significantly associated with poor tumor differentiation (P=0.023), advanced clinical stage (P=0.021), and poor overall survival (OS; P=0.034). Univariate and multivariate analyses revealed that STYK1expression was an independent prognostic indicator (HR =0.53, 95% CI =0.29–0.95, P=0.039; HR =0.51, 95% CI =0.24–0.91, P=0.030, respectively).
Conclusion: Downregulated STYK1 expression correlated significantly with poor tumor differentiation, advanced clinical stage, and poor OS in GC. STYK1 might be a diagnostic and prognostic indicator in patients with GC.

Keywords: gastric cancer, STYK1, prognosis, overall survival

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