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Low expression of ZMYND8 correlates with aggressive features and poor prognosis in nasopharyngeal carcinoma

Authors Chen J, Liu J, Chen X, Li Y, Li Z, Shen C, Chen K, Zhang X

Received 28 March 2019

Accepted for publication 4 July 2019

Published 21 August 2019 Volume 2019:11 Pages 7835—7843

DOI https://doi.org/10.2147/CMAR.S210305

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Nakshatri


Jiewei Chen,1,2,* Jun Liu,1,2,* Xiaoting Chen,1,2,* Yong Li,1,2 Zizi Li,3 Chengchao Shen,1,2 Keming Chen,1,2 Xinke Zhang1,2

1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Department of Pathology, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Xinke Zhang
Department of Pathology, Sun Yat-sen University Cancer Center, 651 Dong Feng Road East, Guangzhou 510060, People’s Republic of China
Tel +86 208 734 2270
Email zhangxk@sysucc.org.cn

Purpose: ZMYND8 is closely correlated with cancerous proliferation and invasiveness. However, its prognostic value has not been estimated in a nasopharyngeal carcinoma (NPC). The purpose of this study was to elucidate the status of ZMYND8 expression and its prognostic significance in NPCs.
Methods: The status of ZMYND8 expression was investigated by immunohistochemistry for NPC samples in the study. The cutoff value of ZMYND8 expression was confirmed in NPCs using ROC-curve analysis. Correlations between ZMYND8 expression and clinicopathological variables and patient prognosis were analyzed by various statistical methods.
Results: Our study showed that low expression of ZMYND8 strongly correlated with late T stage in NPCs (P<0.05). Kaplan–Meier survival analysis revealed a significant association between low ZMYND8 expression and worse overall survival (P<0.05). Most importantly, Cox regression analysis confirmed ZMYND8 expression in NPC could be an independent prognostic factor.
Conclusion: Low expression of ZMYND8 could be of importance, due to its displaying more aggressive behavior in NPC. Therefore, ZMYND8 expression might serve as an independent prediction factor in patients with NPCs.

Keywords: ZMYND8, nasopharyngeal carcinoma, prognosis

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