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Long term safety, efficacy, and patient acceptability of hyaluronic acid injection in patients with painful osteoarthritis of the knee

Authors McArthur, Dy C, Fabricant P, Gonzalez Della Valle

Received 19 July 2012

Accepted for publication 26 October 2012

Published 12 December 2012 Volume 2012:6 Pages 905—910


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Benjamin A McArthur, Christopher J Dy, Peter D Fabricant, Alejandro Gonzalez Della Valle

Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA

Abstract: The increasing prevalence of painful knee osteoarthritis has created an additional demand for pharmacologic management to prevent or delay surgical management. Viscosupplementation, via intraarticular injection of hyaluronic acid (HA), aims to restore the favorable milieu present in the nonarthritic joint. The safety profile of intraarticular HA injections for painful knee osteoarthritis is well established, with the most common adverse effect being a self-limited reaction at the injection site. Although acceptance of the early literature has been limited by publication bias and poor study quality, more recent and rigorous meta-analysis suggests that intraarticular HA injection is superior to placebo injection for pain relief and matches, if not surpasses, the effect size of other nonoperative treatments, such as nonsteroidal anti-inflammatory medication. Intraarticular HA injection is effective in providing temporary pain relief in patients with painful knee osteoarthritis. Future investigations should focus on optimizing the composition and administration of HA agents to provide prolonged relief of painful osteoarthritis in the knee and other joints.

Keywords: intraarticular injection, hyaluronate, viscosupplementation, osteoarthritis, knee

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