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Long-term safety and efficacy of telmisartan/amlodipine single pill combination in the treatment of hypertension

Authors Billecke SS, Marcovitz PA

Received 30 November 2012

Accepted for publication 24 December 2012

Published 16 March 2013 Volume 2013:9 Pages 95—104

DOI https://doi.org/10.2147/VHRM.S40963

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Scott S Billecke, Pamela A Marcovitz

Beaumont Health System, Ministrelli Women’s Heart Center, Royal Oak, MI, USA

Abstract: The use of multiple drug regimens is increasingly recognized as a tacit requirement for the management of hypertension, a necessity fueled in part by rising rates of metabolic syndrome and diabetes. By targeting complementary pathways, combinations of antihypertensive drugs can be applied to provide effective blood pressure control while minimizing side effects and reducing exposure to high doses of individual medications. In addition, combination therapies, including angiotensin converting enzyme (ACE) inhibitors and calcium channel blockers (CCBs), have the added benefit of reducing cardiovascular mortality and morbidity over other dual therapies while providing equivalent blood pressure control. It is possible that angiotensin receptor blockers (ARBs), which unlike ACE inhibitors are minimally affected by upregulation of alternative pathways for angiotensin II accumulation following long-term treatment, would also provide such outcome benefits. At issue, however, is maintaining patient compliance, as adding medications is known to reduce adherence to treatment regimens. The purpose of this review is to summarize existing trial data for the long-term safety and efficacy of a recent addition to the armamentarium of dual-antihypertensive therapeutic options, the telmisartan/amlodipine single pill combination. The areas where long-term data are lacking, notably clinical information regarding minorities and women, will also be discussed.

Keywords: Angiotensin receptor blocker, antihypertensive, calcium channel blocker, clinical trial, combination pill

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