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Livestock-Associated and Non-Livestock-Associated Staphylococcus aureus Carriage in Humans is Associated with Pig Exposure in a Dose–Response Manner

Authors Liu Y, Li W, Dong Q, Liu Y, Ye X

Received 5 November 2020

Accepted for publication 23 December 2020

Published 19 January 2021 Volume 2021:14 Pages 173—184

DOI https://doi.org/10.2147/IDR.S290655

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Sahil Khanna


Yanling Liu, Wenhui Li, Qian Dong, Yangqun Liu, Xiaohua Ye

School of Public Health, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China

Correspondence: Yangqun Liu; Xiaohua Ye
School of Public Health, Guangdong Pharmaceutical University, 283# Jianghai Dadao, Haizhu District, Guangzhou, People’s Republic of China
Tel +862034055355
Email 136437677@qq.com; smalltomato@163.com

Background: The distinction between livestock-associated and human-associated methicillin-resistant Staphylococcus aureus (MRSA) has become more and more blurred. This study aimed to reveal the transmission risk of livestock-associated and non-livestock-associated S. aureus (including MRSA and multidrug-resistant S. aureus [MDRSA]) by occupational pig exposure.
Methods: A total of 591 pig-exposed workers and 1178 non-exposed workers were enrolled in this study. All nasal S. aureus isolates were tested for antibiotic susceptibility and molecular characteristics. Logistic regression models were used to examine the dose–response relationships between occupational pig exposure and S. aureus carriage.
Results: Pig-exposed workers had significantly higher carriage rates of MRSA (OR=6.29, 95% CI: 3.38∼ 11.68) and MDRSA (OR=3.17, 95% CI: 2.03∼ 4.96) than non-exposed workers. Notably, we found dose–response relationships between occupational pig exposure and MRSA or MDRSA carriage. Using genotypic and phenotypic markers for differentiating livestock-associated and non-livestock-associated S. aureus, we also revealed dose–response relationships occupational pig exposure and livestock-associated or non-livestock-associated S. aureus carriage.
Conclusion: Our findings provide sufficient epidemiological evidence for revealing the high transmission risk of livestock-associated S. aureus and the low transmission risk of non-livestock-associated S. aureus by occupational pig exposure.

Keywords: livestock, human, methicillin-resistant S. aureus, multidrug-resistant S. aureus, transmission

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