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Liquid crystal nanoparticle formulation as an oral drug delivery system for liver-specific distribution

Authors Lee DR, Park JS, Bae I, Lee Y, Kim BM

Received 24 September 2015

Accepted for publication 17 December 2015

Published 3 March 2016 Volume 2016:11 Pages 853—871


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Thomas Webster

Dong Ryeol Lee,1,2 Ji Su Park,1 Il Hak Bae,1 Yan Lee,1 B Moon Kim1

1Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea; 2Technology Development Center, BASF Company Ltd., Hwaseong, Gyeonggi-do, Republic of Korea

Abstract: Liquid crystal nanoparticles have been utilized as an efficient tool for drug delivery with enhanced bioavailability, drug stability, and targeted drug delivery. However, the high energy requirements and the high cost of the liquid crystal preparation have been obstacles to their widespread use in the pharmaceutical industry. In this study, we prepared liquid crystal nanoparticles using a phase-inversion temperature method, which is a uniquely low energy process. Particles prepared with the above method were estimated to be ~100 nm in size and exhibited a lamellar liquid crystal structure with orthorhombic lateral packing. Pharmacokinetic and tissue distribution studies of a hydrophobic peptide-based drug candidate formulated with the liquid crystal nanoparticles showed a five-fold enhancement of bioavailability, sustained release, and liver-specific drug delivery compared to a host–guest complex formulation.

Keywords: LCNP, PIT, sustained release, bioavailability

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