Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Liposomes as nanomedical devices

Authors Bozzuto G, Molinari A

Received 5 June 2014

Accepted for publication 11 October 2014

Published 2 February 2015 Volume 2015:10(1) Pages 975—999

DOI https://doi.org/10.2147/IJN.S68861

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Dr Thomas J Webster

Giuseppina Bozzuto,1,2 Agnese Molinari2

1Chemical Methodology Institute, CNR, 2Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy

Abstract: Since their discovery in the 1960s, liposomes have been studied in depth, and they continue to constitute a field of intense research. Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier system known to date. Notable progress has been made, and several biomedical applications of liposomes are either in clinical trials, are about to be put on the market, or have already been approved for public use. In this review, we briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization. Moreover, we discuss the influence of the physicochemical properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. Finally, we describe some strategies developed to overcome limitations of the “first-generation” liposomes, and liposome-based drugs on the market and in clinical trials.

Keywords: liposomes, nanomedicine, drug delivery, ultrastructure


Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Barriers to medical device innovation

Bergsland J, Elle OJ, Fosse E

Medical Devices: Evidence and Research 2014, 7:205-209

Published Date: 13 June 2014

Production and analysis of a biosimilar erythropoietin in Egypt

Ebied WM, Ahmed HM, Elbarbry FA

Biosimilars 2014, 4:11-22

Published Date: 10 May 2014

Development of a liposome-based formulation for vitamin K1 nebulization on the skin

Campani V, Marchese D, Pitaro MT, Pitaro M, Grieco P, De Rosa G

International Journal of Nanomedicine 2014, 9:1823-1832

Published Date: 10 April 2014

Porcine dermis implants in soft-tissue reconstruction: current status

Smart NJ, Bryan N, Hunt JA, Daniels IR

Biologics: Targets and Therapy 2014, 8:83-90

Published Date: 10 March 2014