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Lipid metabolism in chronic obstructive pulmonary disease

Authors Chen H, Li Z, Dong L, Wu Y, Shen H, Chen Z

Received 27 November 2018

Accepted for publication 19 March 2019

Published 13 May 2019 Volume 2019:14 Pages 1009—1018

DOI https://doi.org/10.2147/COPD.S196210

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Chunxue Bai


Haipin Chen,1 Zhouyang Li,1 Lingling Dong,1 Yinfang Wu,1 Huahao Shen,1,2 Zhihua Chen1

1Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Institute of Respiratory Diseases, Hangzhou, Zhejiang, People’s Republic of China; 2State Key Lab of Respiratory Disease, Guangzhou, Guangdong, People’s Republic of China

Abstract: Dysregulated lipid metabolism plays crucial roles in various diseases, including diabetes mellitus, cancer, and neurodegeneration. Recent studies suggest that alterations in major lipid metabolic pathways contribute to pathogenesis of lung diseases, including chronic obstructive pulmonary disease (COPD). These changes allow lung tissue to meet the energy needs and trigger anabolic pathways that initiate the synthesis of active molecules directly involved in the inflammation. In this review, we summarize the changes of catabolism and anabolism of lipids, lipid molecules including lipid mediators, lipid synthesis transcription factors, cholesterol, and phospholipids, and how those lipid molecules participate in the initiation and resolution of inflammation in COPD.

Keywords: COPD, lipid metabolism, airway inflammation

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