Back to Journals » Patient Preference and Adherence » Volume 8

Life-threatening asthma attack during prolonged fingolimod treatment: case report

Authors Zecca C, Caporro M, Györik S, Gobbi C

Received 8 April 2014

Accepted for publication 14 May 2014

Published 14 July 2014 Volume 2014:8 Pages 987—989


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Chiara Zecca,1,* Matteo Caporro,1,* Sandor Györik,2 Claudio Gobbi1

1Neurocenter of Southern Switzerland, Department of Neurology, Ospedale Regionale di Lugano, Lugano, Switzerland; 2Department of Internal Medicine, Ospedale Regionale di Bellinzona, Bellinzona, Switzerland

*These authors contributed equally to this work

Background: Fingolimod (FTY) mediates bronchoconstriction by interacting with sphingosine-1-phosphate receptors. The majority of the reported adverse respiratory events occur during the first weeks of treatment.
Case presentation: A 49-year-old woman developed a life-threatening asthma attack after 6 months of continuous FTY treatment. The adverse event required prolonged hospitalization, and the patient recovered without sequelae after FTY interruption. A history of previous airway hyperreactivity and a concurrent viral respiratory infection possibly acted as predisposing factors.
Conclusion: This first description of a severe, life-threatening asthma attack during prolonged FTY treatment suggests the need for long-term clinical surveillance, especially in patients with known predisposing factors.

Keywords: multiple sclerosis, bronchial hyper-reactivity

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]