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Leg ulcers in sickle cell patients: management challenges
Authors El Khatib AM, Hayek SN
Received 4 December 2015
Accepted for publication 15 June 2016
Published 15 November 2016 Volume 2016:3 Pages 157—161
DOI https://doi.org/10.2147/CWCMR.S85455
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Marco Romanelli
Arij M El Khatib,1 Shady N Hayek2
1Division of Plastic and Reconstructive Surgery, Department of Surgery, American University of Beirut Medical Center (AUBMC), 2Private Practice, Cosmetic Surgery Center, Beirut, Lebanon
Abstract: Sickle cell disease is an autosomal recessive hemoglobinopathy caused by an amino acid substitution from glutamic acid to valine in the beta hemoglobin chain. One of the common symptoms occurring in sickle cell patients are leg ulcers, which are notoriously painful, difficult to treat, and frequently recurrent. These ulcers pose a therapeutic challenge with multiple modalities proposed for treatment, but with scarce evidence of efficacy of any single modality. Ulcer prevention, rigorous wound care, pain control, and surgery are the current mainstays of sickle cell leg ulcer treatment.
Keywords: sickle cell leg ulcer, leg wound, sickle cell disease
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