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Left atrial appendage closure devices for cardiovascular risk reduction in atrial fibrillation patients

Authors Cruz-Gonzalez I, Rama-Merchan JC, Rodriguez-Collado J, Martin-Moreiras J, Diego-Nieto A, Arribas-Jimenez A, Sanchez PL

Received 11 December 2014

Accepted for publication 16 January 2015

Published 13 May 2015 Volume 2015:6 Pages 47—56

DOI https://doi.org/10.2147/RRCC.S48337

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Richard Kones


Ignacio Cruz-Gonzalez,* Juan Carlos Rama-Merchan,* Javier Rodriguez-Collado, Javier Martin-Moreiras, Alejandro Diego-Nieto, Antonio Arribas-Jimenez, Pedro Luís Sanchez

Department of Cardiology, University Hospital of Cardiology and IBSAL, Salamanca, Spain

*Ignacio Cruz-Gonzalez and Juan Carlos Rama-Merchan have contributed equally to this work and should be considered co-first authors


Abstract: Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF is associated with a 4–5-fold increased risk of stroke and systemic embolism. Oral anticoagulant is the first-line therapy for this purpose, but it has various limitations and is often contraindicated or underutilized. Autopsy and surgical data have suggested that 90% of atrial thrombi in nonvalvular AF patients originate from the left atrial appendage, leading to the development of percutaneous closure for thromboembolic prevention. This paper examines the current evidence on left atrial appendage closure devices for cardiovascular risk reduction in AF patients.


Keywords: atrial fibrillation, left atrial appendage, stroke, oral anticoagulant, percutaneous closure, thromboembolic prevention

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