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Intraoperative anaphylaxis to gelatin-based hemostatic agents: a case report

Authors Lied GA, Lund KB, Storaas T

Received 24 January 2019

Accepted for publication 22 May 2019

Published 18 June 2019 Volume 2019:12 Pages 163—167

DOI https://doi.org/10.2147/JAA.S202784

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 4

Editor who approved publication: Dr Amrita Dosanjh


Gülen Arslan Lied,1–3 Kjetil Børve Lund,4 Torgeir Storaas2

1Department of Clinical Medicine, University of Bergen, Bergen, Norway; 2Section of Clinical Allergy, Department of Occupational Diseases, 3Section of Gastroenterology, Department of Medicine, 4Department for Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway

Abstract: Surgiflo Haemostatic Matrix is an absorbable gelatin matrix hemostatic material that has been widely used in various surgical operations to assist hemostasis. Nonetheless, as biologically active agents (contains porcine gelatin), there is potential for allergic reactions to these products. Here, we report the case of a 71-year-old man who had intraoperative anaphylaxis with cardiovascular events to gelatin associated with the use of a topical hemostatic agent (Surgiflo). The patient reported a history of red meat allergy and tick bites during his allergological examination after anaphylaxis. He also had high levels of specific IgE antibodies towards alpha-gal. Special consideration should be given before administering bovine- or porcine-derived gelatin products during surgery to patients with animal-related allergies, such as alpha-gal or gelatin allergy and an atopic background.

Keywords: gelatin allergy, alpha-gal allergy, hemostatic agents, anaphylaxis

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