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Inorganic nanoparticles kill Toxoplasma gondii via changes in redox status and mitochondrial membrane potential

Authors Adeyemi OS, Murata Y, Sugi T, Kato K

Received 12 September 2016

Accepted for publication 22 November 2016

Published 28 February 2017 Volume 2017:12 Pages 1647—1661


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Webster

Oluyomi Stephen Adeyemi,1,2 Yuho Murata,1 Tatsuki Sugi,1 Kentaro Kato1

1National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan; 2Medicinal Biochemistry and Toxicology Laboratory, Department of Biological Sciences, Landmark University, Omu-Aran, Nigeria

Abstract: This study evaluated the anti-Toxoplasma gondii potential of gold, silver, and platinum nanoparticles (NPs). Inorganic NPs (0.01–1,000 µg/mL) were screened for antiparasitic activity. The NPs caused >90% inhibition of T. gondii growth with EC50 values of ≤7, ≤1, and ≤100 µg/mL for gold, silver, and platinum NPs, respectively. The NPs showed no host cell cytotoxicity at the effective anti-T. gondii concentrations; the estimated selectivity index revealed a ≥20-fold activity toward the parasite versus the host cell. The anti-T. gondii activity of the NPs, which may be linked to redox signaling, affected the parasite mitochondrial membrane potential and parasite invasion, replication, recovery, and infectivity potential. Our results demonstrated the antiparasitic potential of NPs. The findings support the further exploration of NPs as a possible source of alternative and effective anti-T. gondii agents.

Keywords: antiparasite, drug screening, nanomedicine, toxoplasmosis

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