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Infiltrating Treg and Th17 Cells of the Prostate Hypertrophy Gland Associated with Propionibacterium Acnes Infection

Authors Radej S, Płaza P, Olender A, Szewc M, Bar K, Maciejewski R

Received 29 September 2020

Accepted for publication 9 November 2020

Published 30 November 2020 Volume 2020:12 Pages 593—597

DOI https://doi.org/10.2147/RRU.S284066

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jan Colli


Sebastian Radej,1 Paweł Płaza,2 Alina Olender,3 Monika Szewc,1 Krzysztof Bar,2 Ryszard Maciejewski1

1Department of Normal Anatomy, Medical University of Lublin, Lublin, Poland; 2Urology and Urological Oncology, Medical University of Lublin, Lublin, Poland; 3Chair and Department of Medical Microbiology, Medical University of Lublin, Lublin, Poland

Correspondence: Sebastian Radej
Department of Normal Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090, Lublin, Poland
Tel/Fax +4881448 6020
Email sebastian.radej@umlub.pl

Purpose: The aim of the study was to evaluate prostate cell infiltration by CD4(+)IL-17(+) and Treg cells in BPH and PCa patients depending on P. acnes infection in the prostate gland.
Patients and Methods: Prostate fragments were collected from 54 patients with PCa and 34 patients with BPH. Rapid ID 32 was used to identify the bacteria. Cells were analyzed by flow cytometry BD FACSCanto II. Statistical analysis was performed using Statistica 7 software (TIBCO Software Inc, USA).
Results: P. acnes was detected in 35% of patients with PCa and 41% of individuals with BPH. The infiltration of CD4(+)IL-17(+) and Treg cells was statistically significantly higher (P = 0.001) in patients with BPH and positive for P. acnes. A statistically considerably higher (P = 0.001) infiltration of Treg cells in treated for PCa with P.acnes infection was also demonstrated.
Conclusion: Prostatitis caused by P. acnes may contribute to the development of BPH and PCa.

Keywords: P. acnes, Treg cells, Th17 cells, benign prostatic hyperplasia, prostate cancer

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