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Increased Risk of Clopidogrel-Induced Gastric Mucosal Erosion in Elderly Chinese Men Harboring the ABCB1 3435T Allele

Authors Duan L, Li M, Wang F, Cai Y, Li H, Zhou W, Li Y, Chen Q, Bai J, Liu H

Received 19 May 2020

Accepted for publication 30 July 2020

Published 20 August 2020 Volume 2020:13 Pages 1237—1244

DOI https://doi.org/10.2147/RMHP.S263625

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Marco Carotenuto


Lei Duan, Man Li, Fan Wang, Yulun Cai, Huiying Li, Wenli Zhou, Yuerui Li, Qiang Chen, Jing Bai, Hongbin Liu

Department of Geriatric Cardiology, National Clinical Research Center for Geriatric Diseases, The Second Medical Center of PLA General Hospital, Beijing 100853, People’s Republic of China

Correspondence: Hongbin Liu Department of Geriatric Cardiology
National Clinical Research Center for Geriatric Diseases, The Second Medical Center of PLA General Hospital, 28 Fuxing Road, Beijing 100853, People’s Republic of China
Tel +86 010 66876349
Email liuhb301@sina.com

Background: It is uncertain whether long-term use of clopidogrel alone can cause gastric mucosal injury. This study aimed to evaluate the relationship between ABCB1 C3435T polymorphisms, which could affect the intestinal absorption of clopidogrel, and gastric mucosal erosion in elderly Chinese men who used clopidogrel alone.
Methods: We selected 298 male patients (aged between 68.2 and 89.5 years, average age 78); 201 of them constituted the control group, and 97 constituted the case group. Patients taking clopidogrel alone who had undergone endoscopic screening for gastric erosion were analyzed for ABCB1 C3435T polymorphisms by a TaqMan assay.
Results: The proportion of people carrying the ABCB1 3435T allele (n = 63, 64.9% vs n = 97, 48.3%, p = 0.007) was significantly higher in the case group than in the control group. After adjustments for significant factors were made, ABCB1 3435T allele carrier (OR 2.14, 95% CI 1.43– 3.84, p < 0.01) was found to be associated with gastric mucosal erosion in people who used clopidogrel alone.
Conclusion: Carrying the ABCB1 3435T allele may be a useful genetic predictor for clopidogrel-induced gastric mucosal erosion in elderly Chinese men.

Keywords: clopidogrel, polymorphism, single nucleotide, ABCB1 C3435T, gastric mucosa, risk factor

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