Improvement of dermal parameters in aged skin after oral use of a nutrient supplement
Received 29 August 2017
Accepted for publication 4 December 2017
Published 30 April 2018 Volume 2018:11 Pages 195—201
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Jeffrey Weinberg
Flávia Alvim Sant’Anna Addor,1 Juliana Cotta Vieira,2 Camila Sirieiro Abreu Melo2
1MEDCIN Research, Osasco, Brazil; 2Farmoquímica S.A., Rio de Janeiro, Brazil
Purpose: Skin aging is a progressive and degenerative process caused by a decrease in the physiological functions of the skin tissue. In addition, environmental factors as well as concomitant diseases and lifestyle (nutrition, sedentary lifestyle, smoking, etc) negatively impact the aging process. An association between oral administration of collagen peptides combined with vitamin C and extracts of Hibiscus sabdariffa and Aristotelia chilensis (Delphynol®) (Eximia Firmalize Age complex®) on dermal thickness was studied and the improvement in aging signs was evaluated.
Patients and methods: Female adult patients received an oral nutritional supplement containing collagen peptides, vitamin C, H. sabdariffa, and A. chilensis (Delphynol) in a sachet and were instructed to consume 1 sachet diluted in 200 mL of water once daily for 12 weeks. They were evaluated clinically, by high frequency ultrasound and cutometry.
Results: There was a significant improvement of firmness and elasticity and an increase in dermal thickness by ultrasound after 3 months of use.
Conclusion: The association of collagen peptides, vitamin C, H. sabdariffa and A. chilensis (Delphynol) could improve the signs of dermal skin aging.
Keywords: aging, collagen, ultrasound, dermis, antioxidant, flavonoids, peptides
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