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Improvement in ocular cicatricial pemphigoid following treatment for porphyria cutanea tarda

Authors Ford M, Khalifa

Received 27 June 2012

Accepted for publication 21 August 2012

Published 24 October 2012 Volume 2012:6 Pages 1709—1712

DOI https://doi.org/10.2147/OPTH.S35402

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


R Marshall Ford, Yousuf M Khalifa

David and Ilene Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY, USA

Abstract: A 64-year-old Caucasian male complaining of redness and tearing for 3 years in both eyes was referred for evaluation of cicatricial conjunctivitis. Ocular cicatricial pemphigoid was suspected and this diagnosis was confirmed through biopsy. The patient's condition showed moderate improvement following treatment with methotrexate and mycophenolate mofetil. The patient was later diagnosed with porphyria cutanea tarda and phlebotomy treatments were subsequently initiated. The patient's ocular symptoms improved further after he began receiving these phlebotomy treatments, and conventional treatment was discontinued. The authors hypothesize that circulating porphyrins activated by ultraviolet light could be the cause of the ocular cicatricial pemphigoid in this patient.

Keywords: cicatricial conjunctivitis, phlebotomy treatments, circulating porphyrins, ultraviolet light

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