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Impact upon clinical outcomes of translation of PNA FISH-generated laboratory data from the clinical microbiology bench to bedside in real time

Authors Ly T, Gulia J, Pyrgos V, Waga M, Shoham S

Published 6 June 2008 Volume 2008:4(3) Pages 637—640


Tam Ly, Jyoti Gulia, Vasilios Pyrgos, Masashi Waga, Shmuel Shoham

Section of Infectious Diseases, Washington Hospital Center, Washington DC, USA

Abstract: Fluorescence in situ hybridization using peptide nucleic acid probes (PNA-FISH) differentiates Staphylococcus aureus from other Gram-positive-cocci in clusters (GPCC). 101/202 patients with GPCC+ blood cultures were randomly assigned to clinician-notification of PNA FISH results. Notifi cation was associated with reduced mortality (8% vs.17%, p = 0.05), further antibiotic use (median −2.5 days, p = 0.01), and trended toward reduced hospital stay and charges.

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