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Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation

Authors Keller M, Bollard C

Received 21 February 2014

Accepted for publication 5 April 2014

Published 18 June 2014 Volume 2014:3 Pages 97—106

DOI https://doi.org/10.2147/ITT.S40082

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6


Michael D Keller, Catherine M Bollard

Program for Cell Enhancement and Technologies for Immunotherapy, Sheikh Zayed Institute for Pediatric Surgical Innovation, and Center for Cancer and Immunology Research, Children’s National Health System, Washington, DC, USA

Abstract: Anti-pathogen adoptive T-cell immunotherapy has been proven to be highly effective in preventing or controlling viral infections following hematopoietic stem cell transplantation. Recent advances in manufacturing protocols allow an increased number of targeted pathogens, eliminate the need for viral transduction, broaden the potential donor pool to include pathogen-naïve sources, and reduce the time requirement for production. Early studies suggest that anti-fungal immunotherapy may also have clinical benefit. Future advances include further broadening of the pathogens that can be targeted and development of T-cells with resistance to pharmacologic immunosuppression.

Keywords: immunotherapy, stem cell transplantation, T-cell, virus, fungus


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