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Immune cells: more than simple carriers for systemic delivery of oncolytic viruses

Authors Eisenstein S, Chen S, Pan P

Received 15 May 2014

Accepted for publication 8 August 2014

Published 6 November 2014 Volume 2014:3 Pages 83—91

DOI https://doi.org/10.2147/OV.S47143

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Faris Farassati


Samuel Eisenstein,1 Shu-Hsia Chen,2 Ping-Ying Pan2

1Department of Surgery, 2Department of Oncological Sciences and Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, USA

Abstract: Oncolytic virotherapy on its own has numerous drawbacks, including an inability of the virus to actively target tumor cells and systemic toxicities at the high doses necessary to effectively treat tumors. Addition of immune cell-based carriers of oncolytic viruses holds promise as a technique in which oncolytic virus can be delivered directly to tumors in smaller and less toxic doses. Interestingly, the cell carriers themselves have also demonstrated antitumor effects, which can be augmented further by tailoring the appropriate oncolytic virus to the appropriate cell type. This review discusses the multiple factors that go into devising an effective, cell-based delivery system for oncolytic viruses.

Keywords: oncolytic virus, cell carrier, immune cells, cancer therapy, myeloid-derived suppressor cells

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