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hsa_circRNA_101237: A Novel Diagnostic and Prognostic Biomarker and Potential Therapeutic Target for Multiple Myeloma

Authors Liu X, Tang H, Liu J, Wang X

Received 4 December 2019

Accepted for publication 21 January 2020

Published 20 March 2020 Volume 2020:12 Pages 2109—2118

DOI https://doi.org/10.2147/CMAR.S241089

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Bilikere Dwarakanath


Xiao Liu,1,* Hao Tang,1,* Jing Liu,1 Xiang Wang2

1The Third Xiangya Hospital of Central South University, Changsha 410013, People’s Republic of China; 2Department of Hematology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Xiang Wang
Department of Hematology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of China
Email wangxiangxiangya@126.com

Background: It has been demonstrated that circular RNA (circRNA) plays a crucial role in the occurrence and development of tumors, but the diagnostic and predictive value of most circRNAs in tumor patients remains unclear, especially for multiple myeloma (MM).
Methods: High-throughput circRNA microarray-based sequencing was used to identify the differentially expressed circRNAs in MM. qRT-PCR was then employed to detect hsa_circRNA_101237 expression levels in the bone marrow tissues from 143 MM patients (65 first-episode treatment-naive patients and 78 patients with recurrent/refractory disease), MM cells and bortezomib-resistant MM cell lines. Whether hsa_circRNA_101237 can be used as a potential biomarker and therapeutic target for MM was investigated.
Results: The average expressions of hsa_circRNA_101237 in the bone marrow tissues from MM patients (especially those with recurrent/refractory disease), MM cells and bortezomib-resistant MM cell lines were increased significantly (P< 0.01). hsa_circRNA_101237 was overexpressed in patients positive for 13q14 deletion, 1q21 amplification, P53 deletion, and t(4,14) and t(14,16). hsa_circRNA_101237 was closely related to prognosis of the patients, and its high expression was associated with shorter OS and PFS. In addition, those overexpressing hsa_circRNA_101237 were less responsive to bortezomib treatment. Bioinformatic analysis indicated that hsa_circRNA_101237 interacted with 11 miRNAs and 10 candidate mRNAs. This finding may shed new light on the subsequent studies on the working mechanism and functions.
Conclusion: It was first reported that hsa_circRNA_101237 was significantly upregulated in MM. It was indicated that hsa_circRNA_101237 may be a novel biomarker for MM, and it plays a significant role in the occurrence and development of MM.

Keywords: circRNAs, MM, biomarker, diagnosis, prognosis

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