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Honey and Chamomile Activate Keratinocyte Antioxidative Responses via the KEAP1/NRF2 System

Authors Ogawa T, Ishitsuka Y, Nakamura Y, Okiyama N, Watanabe R, Fujisawa Y, Fujimoto M

Received 8 July 2020

Accepted for publication 24 August 2020

Published 7 September 2020 Volume 2020:13 Pages 657—660

DOI https://doi.org/10.2147/CCID.S270602

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Tatsuya Ogawa, 1 Yosuke Ishitsuka, 1 Yoshiyuki Nakamura, 1 Naoko Okiyama, 1 Rei Watanabe, 1, 2 Yasuhiro Fujisawa, 1 Manabu Fujimoto 1, 2

1Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; 2Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Correspondence: Yosuke Ishitsuka
Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
Tel +81-29-853-3128
Fax +81-29-853-3217
Email yosuke.ishitsuka@md.tsukuba.ac.jp

Introduction: The stratum corneum protects against the entry of pathogens, allergens, and irritants while preventing dehydration. The Kelch-like erythroid cell-derived protein with cap-n-collar homology-associated protein 1 (KEAP1)/NF-E2-related factor 2 (NRF2) system maintains skin barrier homeostasis. Aggregated evidence suggests that NRF2-mediated antioxidative response is hardwired into the stratified squamous epithelia. Honey and chamomile have long been regarded as natural antioxidants. Nonetheless, it is still unclear whether they activate the KEAP1/NRF2 system in the epidermis and could promote epidermal barrier recovery.
Methods: To address the abovementioned issue, we explored the antioxidative property of honey/chamomile extract by using non-cell-based KEAP1-inhibition assay and cultured human epidermal keratinocytes.
Results: Herein we report that the extract inhibited KEAP1-NRF2 interaction and induced keratinocyte production of antioxidant small proline-rich protein.
Conclusion: Our results may offer an opportunity to develop cosmetic products that boost NRF2-mediated antioxidative/antiaging, epidermis-intrinsic bio-responses.

Keywords: NRF2, honey, chamomile, keratinocyte

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