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High-intensity focused ultrasound therapy in combination with gemcitabine for unresectable pancreatic carcinoma

Authors Lv W, Yan T, Wang G, Zhao W, Zhang T, Zhou D

Received 16 June 2015

Accepted for publication 27 November 2015

Published 2 May 2016 Volume 2016:12 Pages 687—691

DOI https://doi.org/10.2147/TCRM.S90567

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 3

Editor who approved publication: Professor Deyun Wang

Wei Lv, Tao Yan, Guojin Wang, Wei Zhao, Tao Zhang, Dinghua Zhou

Hepatobiliary Surgery Department, Second Artillery General Hospital, Xicheng District, Beijing, People’s Republic of China

Objective:
To investigate the therapeutic effect and safety of high-intensity focused ultrasound (HIFU) therapy combined with gemcitabine in treating unresectable pancreatic carcinoma.
Methods: The 45 patients suffering from pancreatic carcinoma were randomized into two groups. The patients in the experimental group (n=23) received HIFU in combination with gemcitabine and those in the control group (n=22) received gemcitabine alone. The effect and clinical benefit rates in the two groups were compared. The median survival time and 6-month and 12-month survival rates were calculated by Kaplan–Meier method and log-rank test.
Results
: The median survival time and 6-month survival rate were significantly higher in the experimental group than in the control group (8.91 months vs 5.53 months, 73.9% vs 40.9%, respectively P<0.05), but 12-month survival rate was not statistically different between the two groups (13.0% vs 4.5%, P>0.05). The clinical benefit rates in the experimental group and the control group were 69.6% and 36.3%, respectively (P<0.05). The pain remission rate in the experimental group was significantly higher than that in the control group (65.2% vs 31.8%, P<0.05).
Conclusion: HIFU in combination with gemcitabine is better than gemcitabine alone. This combinatorial therapy may become a better and effective treatment for unresectable pancreatic carcinoma.

Keywords: pancreatic carcinoma treatment, high-intensity focused ultrasound therapy, gemcitabine

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