High-intensity focused ultrasound therapy in combination with gemcitabine for unresectable pancreatic carcinoma
Authors Lv W, Yan T, Wang G, Zhao W, Zhang T, Zhou D
Received 16 June 2015
Accepted for publication 27 November 2015
Published 2 May 2016 Volume 2016:12 Pages 687—691
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Hoa Le
Peer reviewer comments 3
Editor who approved publication: Professor Deyun Wang
Wei Lv, Tao Yan, Guojin Wang, Wei Zhao, Tao Zhang, Dinghua Zhou
Hepatobiliary Surgery Department, Second Artillery General Hospital, Xicheng District, Beijing, People’s Republic of China
Objective: To investigate the therapeutic effect and safety of high-intensity focused ultrasound (HIFU) therapy combined with gemcitabine in treating unresectable pancreatic carcinoma.
Methods: The 45 patients suffering from pancreatic carcinoma were randomized into two groups. The patients in the experimental group (n=23) received HIFU in combination with gemcitabine and those in the control group (n=22) received gemcitabine alone. The effect and clinical benefit rates in the two groups were compared. The median survival time and 6-month and 12-month survival rates were calculated by Kaplan–Meier method and log-rank test.
Results: The median survival time and 6-month survival rate were significantly higher in the experimental group than in the control group (8.91 months vs 5.53 months, 73.9% vs 40.9%, respectively P<0.05), but 12-month survival rate was not statistically different between the two groups (13.0% vs 4.5%, P>0.05). The clinical benefit rates in the experimental group and the control group were 69.6% and 36.3%, respectively (P<0.05). The pain remission rate in the experimental group was significantly higher than that in the control group (65.2% vs 31.8%, P<0.05).
Conclusion: HIFU in combination with gemcitabine is better than gemcitabine alone. This combinatorial therapy may become a better and effective treatment for unresectable pancreatic carcinoma.
Keywords: pancreatic carcinoma treatment, high-intensity focused ultrasound therapy, gemcitabine
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