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Heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) in prosthetic joint infections: a case series and review

Authors Sivakumar B, Chaudhuri, Vijaysegaran

Received 26 February 2012

Accepted for publication 6 March 2012

Published 11 May 2012 Volume 2012:4 Pages 27—32

DOI https://doi.org/10.2147/ORR.S31222

Review by Single-blind

Peer reviewer comments 3


Brahman Sivakumar,1 Alex Chaudhuri,2 Praveen Vijaysegaran3

1Department of Orthopedic Surgery, Royal Brisbane and Women's Hospital, Herston, 2Department of Infectious Diseases, The Prince Charles Hospital, Chermside, 3Department of Orthopedic Surgery, The Prince Charles Hospital, Chermside, Australia

Abstract: Prosthetic joint infections are notoriously difficult to manage and often result in prolonged antibiotic therapy, which has been identified as contributing to bacterial resistance. Heteroresistant vancomycin-intermediate Staphylococcus aureus is a substrain of methicillin-resistant Staphylococcus aureus associated with a higher affinity for bone and joint infections. Here, we present three cases of heteroresistant vancomycin-intermediate S. aureus prosthetic joint infection at our institution, review the literature, and provide recommendations for the management of such infections in the future.

Keywords: vancomycin, antibiotics, resistance, orthopedics

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